Hello
I just found a big bug!
After installation of nylas-mail-2.2.2-x64.exe. This problem was not present.
Since 20 days, I had not of the problem. I have been forced to uninstall Nylas. and delete the Nylas user folders because an uninstall / reinstallation did not resolve this issue.
I do not know if this problem can be repeated.
I give you step by step how this big problem happened:
1 / when I sent a message with an attached file of 5 MB
2/ I did not get this message error immediately but shortly thereafter ...
but after I saw for synchronization: send of the message in the "sent" folder, this error message was displayed:

before this error message appears, apparently the message was sent (I heard the notification sound of sending),
3 / I found that my internet connection was lost
4 / previously I went on the internet with my internet browser and my internet connection was operational (before writing and sending this message )
Now when I open Nylas:
1 / the synchronization starts ...
2 / Nylas is still trying to send this message to my "Sent" folder
3/This same error message is displayed again
4 / I again lose my internet connection from my computer