Potential performance issue: Unreliable performance of isin() in pandas 1.2.5

[TendouArisu]

Issue Description:

Hello.
I have discovered a performance degradation in the isin() function of pandas version 1.2.5. And I notice that requirements.txt,
and other files show that it depends on pandas version 1.2.5. I am not sure whether this performance problem in pandas will affect this repository. I found some discussions on GitHub related to this issue, including #38340 and #38379.
I also found that cellot/data/cell.py used the influenced api. There may be more files used the influenced api.

Suggestion

I would recommend considering an upgrade to a different version of pandas > 1.2.5 or exploring other solutions to optimize the performance.
Any other workarounds or solutions would be greatly appreciated.
Thank you!