diff --git a/config/graphql.php b/config/graphql.php
index 132e71f355..02f8258ce3 100644
--- a/config/graphql.php
+++ b/config/graphql.php
@@ -42,6 +42,20 @@
         //
     ],
 
+    /*
+    |--------------------------------------------------------------------------
+    | Mutations
+    |--------------------------------------------------------------------------
+    |
+    | Here you may list mutations to be added to the Statamic schema.
+    |
+    | https://statamic.dev/graphql#custom-mutations
+    */
+
+    'mutations' => [
+        //
+    ],
+
     /*
     |--------------------------------------------------------------------------
     | Middleware
diff --git a/src/GraphQL/DefaultSchema.php b/src/GraphQL/DefaultSchema.php
index 6cde23ac0e..1aaed9f1a1 100644
--- a/src/GraphQL/DefaultSchema.php
+++ b/src/GraphQL/DefaultSchema.php
@@ -45,7 +45,7 @@ public function getConfig()
     {
         return [
             'query' => $this->getQueries(),
-            'mutation' => [],
+            'mutation' => $this->getMutations(),
             'middleware' => $this->getMiddleware(),
             'method' => ['GET', 'POST'],
         ];
@@ -82,4 +82,9 @@ private function getMiddleware()
             GraphQL::getExtraMiddleware()
         );
     }
+
+    private function getMutations()
+    {
+        return config('statamic.graphql.mutations', []);
+    }
 }
diff --git a/src/GraphQL/Middleware/CacheResponse.php b/src/GraphQL/Middleware/CacheResponse.php
index 45b6360f5a..73b5b14636 100644
--- a/src/GraphQL/Middleware/CacheResponse.php
+++ b/src/GraphQL/Middleware/CacheResponse.php
@@ -13,6 +13,10 @@ public function handle($request, Closure $next)
             return $next($request);
         }
 
+        if ($this->isMutation($request)) {
+            return $next($request);
+        }
+
         $cache = app(ResponseCache::class);
 
         if ($response = $cache->get($request)) {
@@ -25,4 +29,11 @@ public function handle($request, Closure $next)
 
         return $response;
     }
+
+    protected function isMutation($request): bool
+    {
+        $query = ltrim(strtolower($request->get('query', '')));
+
+        return str_starts_with($query, 'mutation');
+    }
 }