diff --git a/build.gradle b/build.gradle
index 7f41d37257b9..6b19cc01c9a6 100644
--- a/build.gradle
+++ b/build.gradle
@@ -68,6 +68,7 @@ configure(allprojects) { project ->
 			dependency "io.reactivex:rxjava-reactive-streams:1.2.1"
 			dependency "io.reactivex.rxjava2:rxjava:2.2.21"
 			dependency "io.reactivex.rxjava3:rxjava:3.1.0"
+			dependency "io.smallrye.reactive:mutiny:1.0.0"
 			dependency "io.projectreactor.tools:blockhound:1.0.4.RELEASE"
 
 			dependency "com.caucho:hessian:4.0.63"
diff --git a/spring-core/spring-core.gradle b/spring-core/spring-core.gradle
index a4166705d32d..822b6ed58acd 100644
--- a/spring-core/spring-core.gradle
+++ b/spring-core/spring-core.gradle
@@ -49,6 +49,7 @@ dependencies {
 	optional("io.reactivex:rxjava-reactive-streams")
 	optional("io.reactivex.rxjava2:rxjava")
 	optional("io.reactivex.rxjava3:rxjava")
+	optional("io.smallrye.reactive:mutiny")
 	optional("io.netty:netty-buffer")
 	testCompile("io.projectreactor:reactor-test")
 	testCompile("com.google.code.findbugs:jsr305")
diff --git a/spring-core/src/main/java/org/springframework/core/ReactiveAdapterRegistry.java b/spring-core/src/main/java/org/springframework/core/ReactiveAdapterRegistry.java
index a5a8b9295092..4cbb90c0c606 100644
--- a/spring-core/src/main/java/org/springframework/core/ReactiveAdapterRegistry.java
+++ b/spring-core/src/main/java/org/springframework/core/ReactiveAdapterRegistry.java
@@ -24,6 +24,8 @@
 import java.util.concurrent.CompletionStage;
 import java.util.function.Function;
 
+import io.smallrye.mutiny.Multi;
+import io.smallrye.mutiny.Uni;
 import kotlinx.coroutines.CompletableDeferredKt;
 import kotlinx.coroutines.Deferred;
 import org.reactivestreams.Publisher;
@@ -72,6 +74,8 @@ public class ReactiveAdapterRegistry {
 
 	private static final boolean kotlinCoroutinesPresent;
 
+	private static final boolean mutinyPresent;
+
 	static {
 		ClassLoader classLoader = ReactiveAdapterRegistry.class.getClassLoader();
 		reactorPresent = ClassUtils.isPresent("reactor.core.publisher.Flux", classLoader);
@@ -81,6 +85,7 @@ public class ReactiveAdapterRegistry {
 		rxjava3Present = ClassUtils.isPresent("io.reactivex.rxjava3.core.Flowable", classLoader);
 		flowPublisherPresent = ClassUtils.isPresent("java.util.concurrent.Flow.Publisher", classLoader);
 		kotlinCoroutinesPresent = ClassUtils.isPresent("kotlinx.coroutines.reactor.MonoKt", classLoader);
+		mutinyPresent = ClassUtils.isPresent("io.smallrye.mutiny.Uni", classLoader);
 	}
 
 	private final List<ReactiveAdapter> adapters = new ArrayList<>();
@@ -121,6 +126,11 @@ public ReactiveAdapterRegistry() {
 		if (reactorPresent && kotlinCoroutinesPresent) {
 			new CoroutinesRegistrar().registerAdapters(this);
 		}
+
+		// SmallRye Mutiny
+		if (mutinyPresent) {
+			new MutinyRegistrar().registerAdapters(this);
+		}
 	}
 
 
@@ -417,6 +427,23 @@ void registerAdapters(ReactiveAdapterRegistry registry) {
 		}
 	}
 
+	private static class MutinyRegistrar {
+
+		void registerAdapters(ReactiveAdapterRegistry registry) {
+			registry.registerReactiveType(
+					ReactiveTypeDescriptor.singleOptionalValue(Uni.class, ()-> Uni.createFrom().nothing()),
+					uni ->((Uni<?>)uni).convert().toPublisher(),
+					publisher ->  Uni.createFrom().publisher(publisher)
+			);
+
+			registry.registerReactiveType(
+					ReactiveTypeDescriptor.multiValue(Multi.class, ()-> Multi.createFrom().empty()),
+					multi -> (Multi<?>) multi,
+					publisher-> Multi.createFrom().publisher(publisher)
+			);
+		}
+	}
+
 
 	/**
 	 * {@code BlockHoundIntegration} for spring-core classes.
diff --git a/spring-core/src/test/java/org/springframework/core/ReactiveAdapterRegistryTests.java b/spring-core/src/test/java/org/springframework/core/ReactiveAdapterRegistryTests.java
index 4dc08a704f29..535891e6ff3e 100644
--- a/spring-core/src/test/java/org/springframework/core/ReactiveAdapterRegistryTests.java
+++ b/spring-core/src/test/java/org/springframework/core/ReactiveAdapterRegistryTests.java
@@ -21,6 +21,8 @@
 import java.util.List;
 import java.util.concurrent.CompletableFuture;
 
+import io.smallrye.mutiny.Multi;
+import io.smallrye.mutiny.Uni;
 import kotlinx.coroutines.Deferred;
 import org.junit.jupiter.api.Nested;
 import org.junit.jupiter.api.Test;
@@ -357,6 +359,52 @@ void deferred() {
 		}
 	}
 
+	// SmallRye Mutiny
+	@Nested
+	class Mutiny {
+
+		@Test
+		void defaultAdapterRegistrations() {
+			assertThat(getAdapter(io.smallrye.mutiny.Uni.class)).isNotNull();
+			assertThat(getAdapter(io.smallrye.mutiny.Multi.class)).isNotNull();
+		}
+
+		@Test
+		void toUni() {
+			Publisher<Integer> source = Mono.just(1);
+			Object target = getAdapter(Uni.class).fromPublisher(source);
+			assertThat(target).isInstanceOf(Uni.class);
+			assertThat(((Uni<Integer>) target).await().atMost(Duration.ofMillis(1000))).isEqualTo(Integer.valueOf(1));
+		}
+
+		@Test
+		void fromUni() {
+			Uni<Integer> source = Uni.createFrom().item(1);
+			Object target = getAdapter(Uni.class).toPublisher(source);
+			assertThat(target).isInstanceOf(Mono.class);
+			assertThat(((Mono<Integer>) target).block(Duration.ofMillis(1000))).isEqualTo(Integer.valueOf(1));
+		}
+
+		@Test
+		void toMulti() {
+			List<Integer> sequence = Arrays.asList(1, 2, 3);
+			Publisher<Integer> source = Flux.fromIterable(sequence);
+			Object target = getAdapter(Multi.class).fromPublisher(source);
+			assertThat(target).isInstanceOf(Multi.class);
+			assertThat(((Multi<Integer>) target).collect().asList().await().atMost(Duration.ofMillis(1000))).isEqualTo(sequence);
+		}
+
+		@Test
+		void fromMulti() {
+			List<Integer> sequence = Arrays.asList(1, 2, 3);
+			Multi<Integer> source = Multi.createFrom().iterable(sequence);
+			Object target = getAdapter(Multi.class).toPublisher(source);
+			assertThat(target).isInstanceOf(Flux.class);
+			assertThat(((Flux<Integer>) target).blockLast(Duration.ofMillis(1000))).isEqualTo(Integer.valueOf(3));
+		}
+
+	}
+
 	private ReactiveAdapter getAdapter(Class<?> reactiveType) {
 		ReactiveAdapter adapter = this.registry.getAdapter(reactiveType);
 		assertThat(adapter).isNotNull();