diff --git a/tests/run-make/pgo-branch-weights/Makefile b/tests/run-make/pgo-branch-weights/Makefile
index c60206a1f341c..4c9f8b2493ab8 100644
--- a/tests/run-make/pgo-branch-weights/Makefile
+++ b/tests/run-make/pgo-branch-weights/Makefile
@@ -1,5 +1,6 @@
 # needs-profiler-support
 # ignore-windows-gnu
+# ignore-cross-compile
 
 # FIXME(mati865): MinGW GCC miscompiles compiler-rt profiling library but with Clang it works
 # properly. Since we only have GCC on the CI ignore the test for now.
diff --git a/tests/run-make/pgo-gen-lto/Makefile b/tests/run-make/pgo-gen-lto/Makefile
index 3f2f6a838b51c..8b647846af3b3 100644
--- a/tests/run-make/pgo-gen-lto/Makefile
+++ b/tests/run-make/pgo-gen-lto/Makefile
@@ -1,5 +1,6 @@
 # needs-profiler-support
 # ignore-windows-gnu
+# ignore-cross-compile
 
 # FIXME(mati865): MinGW GCC miscompiles compiler-rt profiling library but with Clang it works
 # properly. Since we only have GCC on the CI ignore the test for now.
diff --git a/tests/run-make/pgo-gen/Makefile b/tests/run-make/pgo-gen/Makefile
index 4623a74957b0f..bf32cfdb802f5 100644
--- a/tests/run-make/pgo-gen/Makefile
+++ b/tests/run-make/pgo-gen/Makefile
@@ -1,5 +1,6 @@
 # needs-profiler-support
 # ignore-windows-gnu
+# ignore-cross-compile
 
 # FIXME(mati865): MinGW GCC miscompiles compiler-rt profiling library but with Clang it works
 # properly. Since we only have GCC on the CI ignore the test for now.
diff --git a/tests/run-make/pgo-indirect-call-promotion/Makefile b/tests/run-make/pgo-indirect-call-promotion/Makefile
index 45302215cc64e..542eb244d3959 100644
--- a/tests/run-make/pgo-indirect-call-promotion/Makefile
+++ b/tests/run-make/pgo-indirect-call-promotion/Makefile
@@ -1,5 +1,6 @@
 # needs-profiler-support
 # ignore-windows-gnu
+# ignore-cross-compile
 
 # FIXME(mati865): MinGW GCC miscompiles compiler-rt profiling library but with Clang it works
 # properly. Since we only have GCC on the CI ignore the test for now.
diff --git a/tests/run-make/pgo-use/Makefile b/tests/run-make/pgo-use/Makefile
index 3bac9b77aa39c..9f440118daee3 100644
--- a/tests/run-make/pgo-use/Makefile
+++ b/tests/run-make/pgo-use/Makefile
@@ -1,5 +1,6 @@
 # needs-profiler-support
 # ignore-windows-gnu
+# ignore-cross-compile
 
 # FIXME(mati865): MinGW GCC miscompiles compiler-rt profiling library but with Clang it works
 # properly. Since we only have GCC on the CI ignore the test for now.
diff --git a/tests/run-make/pointer-auth-link-with-c/Makefile b/tests/run-make/pointer-auth-link-with-c/Makefile
index dffbd303582ec..8fcf10e2096cd 100644
--- a/tests/run-make/pointer-auth-link-with-c/Makefile
+++ b/tests/run-make/pointer-auth-link-with-c/Makefile
@@ -1,6 +1,7 @@
 include ../tools.mk
 
 # only-aarch64
+# ignore-cross-compile
 
 all:
 	$(COMPILE_OBJ) $(TMPDIR)/test.o test.c
diff --git a/tests/run-make/profile/Makefile b/tests/run-make/profile/Makefile
index fffc051adbf8e..7919b18ba74a5 100644
--- a/tests/run-make/profile/Makefile
+++ b/tests/run-make/profile/Makefile
@@ -1,4 +1,5 @@
 # needs-profiler-support
+# ignore-cross-compile
 
 include ../tools.mk