diff --git a/Lib/ensurepip/__init__.py b/Lib/ensurepip/__init__.py
index 545fce656fd6f5..e07fa388ce9036 100644
--- a/Lib/ensurepip/__init__.py
+++ b/Lib/ensurepip/__init__.py
@@ -59,12 +59,12 @@ def _disable_pip_configuration_settings():
     os.environ['PIP_CONFIG_FILE'] = os.devnull
 
 
-def bootstrap(*, root=None, upgrade=False, user=False,
+def bootstrap(*, root=None, prefix=None, upgrade=False, user=False,
               altinstall=False, default_pip=False,
               verbosity=0):
     """
     Bootstrap pip into the current Python installation (or the given root
-    directory).
+    and prefix directory).
 
     Note that calling this function will alter both sys.path and os.environ.
     """
@@ -122,6 +122,8 @@ def _bootstrap(*, root=None, upgrade=False, user=False,
         args = ["install", "--no-index", "--find-links", tmpdir]
         if root:
             args += ["--root", root]
+        if prefix:
+            args += ["--prefix", prefix]
         if upgrade:
             args += ["--upgrade"]
         if user:
@@ -193,6 +195,11 @@ def _main(argv=None):
         default=None,
         help="Install everything relative to this alternate root directory.",
     )
+    parser.add_argument(
+        "--prefix",
+        default=None,
+        help="Install everything using this prefix.",
+    )
     parser.add_argument(
         "--altinstall",
         action="store_true",
@@ -212,6 +219,7 @@ def _main(argv=None):
 
     return _bootstrap(
         root=args.root,
+        prefix=args.prefix,
         upgrade=args.upgrade,
         user=args.user,
         verbosity=args.verbosity,
diff --git a/Makefile.pre.in b/Makefile.pre.in
index caa1d376485343..a5634e8b3dee68 100644
--- a/Makefile.pre.in
+++ b/Makefile.pre.in
@@ -1188,7 +1188,7 @@ install: @FRAMEWORKINSTALLFIRST@ commoninstall bininstall maninstall @FRAMEWORKI
 			install|*) ensurepip="" ;; \
 		esac; \
 		$(RUNSHARED) $(PYTHON_FOR_BUILD) -m ensurepip \
-			$$ensurepip --root=$(DESTDIR)/ ; \
+			$$ensurepip --root=$(DESTDIR)/ --prefix=$(prefix) ; \
 	fi
 
 altinstall: commoninstall
@@ -1198,7 +1198,7 @@ altinstall: commoninstall
 			install|*) ensurepip="--altinstall" ;; \
 		esac; \
 		$(RUNSHARED) $(PYTHON_FOR_BUILD) -m ensurepip \
-			$$ensurepip --root=$(DESTDIR)/ ; \
+			$$ensurepip --root=$(DESTDIR)/ --prefix=$(prefix) ; \
 	fi
 
 commoninstall:  check-clean-src @FRAMEWORKALTINSTALLFIRST@ \