diff --git a/Lib/pdb.py b/Lib/pdb.py
index 4a4a0b9d90f6d2..fb7b0eccd16d1c 100755
--- a/Lib/pdb.py
+++ b/Lib/pdb.py
@@ -153,6 +153,7 @@ def namespace(self):
             __name__='__main__',
             __file__=self,
             __builtins__=__builtins__,
+            __spec__=None,
         )
 
     @property
diff --git a/Lib/test/test_pdb.py b/Lib/test/test_pdb.py
index eed02737e8bd48..15d9eaa1f93cb2 100644
--- a/Lib/test/test_pdb.py
+++ b/Lib/test/test_pdb.py
@@ -1862,6 +1862,18 @@ def bœr():
             ('bœr', 1),
         )
 
+    def test_spec(self):
+        # Test that __main__.__spec__ is set to None when running a script
+        script = """
+            import __main__
+            print(__main__.__spec__)
+        """
+
+        commands = "continue"
+
+        stdout, _ = self.run_pdb_script(script, commands)
+        self.assertIn('None', stdout)
+
     def test_issue7964(self):
         # open the file as binary so we can force \r\n newline
         with open(os_helper.TESTFN, 'wb') as f:
diff --git a/Misc/NEWS.d/next/Library/2024-02-29-20-06-06.gh-issue-87115.FVMiOR.rst b/Misc/NEWS.d/next/Library/2024-02-29-20-06-06.gh-issue-87115.FVMiOR.rst
new file mode 100644
index 00000000000000..844340583cd456
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2024-02-29-20-06-06.gh-issue-87115.FVMiOR.rst
@@ -0,0 +1 @@
+Set ``__main__.__spec__`` to ``None`` when running a script with :mod:`pdb`