diff --git a/.github/workflows/misc_0.yml b/.github/workflows/misc_0.yml
index 1497bbe8c45..3fb9266cc02 100644
--- a/.github/workflows/misc_0.yml
+++ b/.github/workflows/misc_0.yml
@@ -66,44 +66,6 @@ jobs:
       - name: Run tests
         run: tox -e tracecontext
 
-  mypy:
-    name: mypy
-    runs-on: ubuntu-latest
-    timeout-minutes: 30
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python 3.11
-        uses: actions/setup-python@v5
-        with:
-          python-version: "3.11"
-
-      - name: Install tox
-        run: pip install tox
-
-      - name: Run tests
-        run: tox -e mypy
-
-  mypyinstalled:
-    name: mypyinstalled
-    runs-on: ubuntu-latest
-    timeout-minutes: 30
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python 3.11
-        uses: actions/setup-python@v5
-        with:
-          python-version: "3.11"
-
-      - name: Install tox
-        run: pip install tox
-
-      - name: Run tests
-        run: tox -e mypyinstalled
-
   typecheck:
     name: typecheck
     runs-on: ubuntu-latest
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 85ab5a84852..bac47c6bc01 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -7,11 +7,12 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ## Unreleased
 
+- typecheck: add sdk/resources and drop mypy
+  ([#4578](https://github.com/open-telemetry/opentelemetry-python/pull/4578))
 - Refactor `BatchLogRecordProcessor` to simplify code and make the control flow more
   clear ([#4562](https://github.com/open-telemetry/opentelemetry-python/pull/4562/)
   and [#4535](https://github.com/open-telemetry/opentelemetry-python/pull/4535)).
 
-
 ## Version 1.33.0/0.54b0 (2025-05-09)
 
 - Fix intermittent `Connection aborted` error when using otlp/http exporters
diff --git a/dev-requirements.txt b/dev-requirements.txt
index a2a55bc88b0..cd203a12104 100644
--- a/dev-requirements.txt
+++ b/dev-requirements.txt
@@ -1,7 +1,6 @@
 pylint==3.3.4
 httpretty==1.1.4
 pyright==1.1.396
-mypy==1.9.0
 sphinx==7.1.2
 sphinx-rtd-theme==2.0.0rc4
 sphinx-autodoc-typehints==1.25.2
diff --git a/mypy-relaxed.ini b/mypy-relaxed.ini
deleted file mode 100644
index 34538bdd797..00000000000
--- a/mypy-relaxed.ini
+++ /dev/null
@@ -1,22 +0,0 @@
-; This is mainly intended for unit tests and such. So probably going forward, we
-; will disable even more warnings here.
-[mypy]
-  disallow_any_unimported = True
-; disallow_any_expr = True
-  disallow_any_decorated = True
-; disallow_any_explicit = True
-  disallow_any_generics = True
-  disallow_subclassing_any = True
-  disallow_untyped_calls = True
-; disallow_untyped_defs = True
-  disallow_incomplete_defs = True
-  check_untyped_defs = True
-  disallow_untyped_decorators = True
-  allow_untyped_globals = True
-; Due to disabling some other warnings, unused ignores may occur.
-;  warn_unused_ignores = True
-  warn_return_any = True
-  strict_equality = True
-
-[mypy-setuptools]
-  ignore_missing_imports = True
diff --git a/mypy.ini b/mypy.ini
deleted file mode 100644
index 4c368fcd944..00000000000
--- a/mypy.ini
+++ /dev/null
@@ -1,22 +0,0 @@
-[mypy]
-  disallow_any_unimported = True
-  disallow_any_expr = True
-  disallow_any_decorated = True
-; disallow_any_explicit = True
-  disallow_any_generics = True
-  disallow_subclassing_any = True
-  disallow_untyped_calls = True
-  disallow_untyped_defs = True
-  disallow_incomplete_defs = True
-  check_untyped_defs = True
-  disallow_untyped_decorators = True
-  warn_unused_configs = True
-  warn_unused_ignores = True
-  warn_return_any = True
-  warn_redundant_casts = True
-  strict_equality = True
-  strict_optional = True
-  no_implicit_optional =  True
-  no_implicit_reexport = True
-  # https://mypy.readthedocs.io/en/stable/running_mypy.html#follow-imports
-  follow_imports = silent
diff --git a/opentelemetry-sdk/src/opentelemetry/sdk/resources/__init__.py b/opentelemetry-sdk/src/opentelemetry/sdk/resources/__init__.py
index 752b9067b77..9038d51334d 100644
--- a/opentelemetry-sdk/src/opentelemetry/sdk/resources/__init__.py
+++ b/opentelemetry-sdk/src/opentelemetry/sdk/resources/__init__.py
@@ -67,7 +67,7 @@
 from json import dumps
 from os import environ
 from types import ModuleType
-from typing import List, MutableMapping, Optional, cast
+from typing import List, Optional, cast
 from urllib import parse
 
 from opentelemetry.attributes import BoundedAttributes
@@ -77,7 +77,10 @@
     OTEL_SERVICE_NAME,
 )
 from opentelemetry.semconv.resource import ResourceAttributes
-from opentelemetry.util._importlib_metadata import entry_points, version
+from opentelemetry.util._importlib_metadata import (
+    entry_points,  # type: ignore[reportUnknownVariableType]
+    version,
+)
 from opentelemetry.util.types import AttributeValue
 
 psutil: Optional[ModuleType] = None
@@ -210,7 +213,7 @@ def create(
                             entry_points(
                                 group="opentelemetry_resource_detector",
                                 name=resource_detector.strip(),
-                            )  # type: ignore
+                            )  # type: ignore[reportUnknownArgumentType]
                         )
                     ).load()()
                 )
@@ -266,8 +269,8 @@ def merge(self, other: "Resource") -> "Resource":
         Returns:
             The newly-created Resource.
         """
-        merged_attributes = self.attributes.copy()  # type: ignore
-        merged_attributes.update(other.attributes)  # type: ignore
+        merged_attributes = dict(self.attributes).copy()
+        merged_attributes.update(other.attributes)
 
         if self.schema_url == "":
             schema_url = other.schema_url
@@ -282,7 +285,7 @@ def merge(self, other: "Resource") -> "Resource":
                 other.schema_url,
             )
             return self
-        return Resource(merged_attributes, schema_url)  # type: ignore
+        return Resource(merged_attributes, schema_url)
 
     def __eq__(self, other: object) -> bool:
         if not isinstance(other, Resource):
@@ -294,16 +297,13 @@ def __eq__(self, other: object) -> bool:
 
     def __hash__(self) -> int:
         return hash(
-            f"{dumps(self._attributes.copy(), sort_keys=True)}|{self._schema_url}"  # type: ignore
+            f"{dumps(self._attributes.copy(), sort_keys=True)}|{self._schema_url}"
         )
 
     def to_json(self, indent: Optional[int] = 4) -> str:
-        attributes: MutableMapping[str, AttributeValue] = dict(
-            self._attributes
-        )
         return dumps(
             {
-                "attributes": attributes,  # type: ignore
+                "attributes": dict(self.attributes),
                 "schema_url": self._schema_url,
             },
             indent=indent,
@@ -334,7 +334,7 @@ class OTELResourceDetector(ResourceDetector):
     # pylint: disable=no-self-use
     def detect(self) -> "Resource":
         env_resources_items = environ.get(OTEL_RESOURCE_ATTRIBUTES)
-        env_resource_map = {}
+        env_resource_map: dict[str, AttributeValue] = {}
 
         if env_resources_items:
             for item in env_resources_items.split(","):
@@ -392,7 +392,7 @@ def detect(self) -> "Resource":
             resource_info[PROCESS_PARENT_PID] = os.getppid()
 
         if psutil is not None:
-            process: psutil_module.Process = psutil.Process()
+            process = psutil.Process()
             username = process.username()
             resource_info[PROCESS_OWNER] = username
 
@@ -483,7 +483,7 @@ def detect(self) -> "Resource":
         )
 
 
-class _HostResourceDetector(ResourceDetector):
+class _HostResourceDetector(ResourceDetector):  # type: ignore[reportUnusedClass]
     """
     The HostResourceDetector detects the hostname and architecture attributes.
     """
diff --git a/pyproject.toml b/pyproject.toml
index ba590c2758e..8879064e7c4 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -113,7 +113,6 @@ exclude = [
   "opentelemetry-sdk/src/opentelemetry/sdk/_events",
   "opentelemetry-sdk/src/opentelemetry/sdk/_logs",
   "opentelemetry-sdk/src/opentelemetry/sdk/error_handler",
-  "opentelemetry-sdk/src/opentelemetry/sdk/resources",
   "opentelemetry-sdk/src/opentelemetry/sdk/metrics",
   "opentelemetry-sdk/src/opentelemetry/sdk/trace",
   "opentelemetry-sdk/src/opentelemetry/sdk/util",
@@ -124,4 +123,5 @@ exclude = [
 strict = [
   "opentelemetry-semantic-conventions",
   "opentelemetry-sdk/src/opentelemetry/sdk/environment_variables",
+  "opentelemetry-sdk/src/opentelemetry/sdk/resources",
 ]
diff --git a/tox.ini b/tox.ini
index 83b8fc2dce0..72cf9f4feae 100644
--- a/tox.ini
+++ b/tox.ini
@@ -88,7 +88,6 @@ envlist =
 
     spellcheck
     tracecontext
-    mypy,mypyinstalled
     typecheck
     docs
     docker-tests-{otlpexporter,opencensus}
@@ -103,9 +102,6 @@ deps =
   coverage: pytest
   coverage: pytest-cov
 
-  mypy,mypyinstalled: -c {toxinidir}/dev-requirements.txt
-  mypy,mypyinstalled: mypy
-
   api: -r {toxinidir}/opentelemetry-api/test-requirements.txt
 
   sdk: -r {toxinidir}/opentelemetry-sdk/test-requirements.txt
@@ -145,7 +141,6 @@ deps =
 
   propagator-jaeger: -r {toxinidir}/propagator/opentelemetry-propagator-jaeger/test-requirements.txt
 
-  mypyinstalled: -e {toxinidir}/opentelemetry-api
 
   getting-started: -r {toxinidir}/docs/getting_started/tests/requirements.txt
   getting-started: {env:CONTRIB_REPO}\#egg=opentelemetry-util-http&subdirectory=util/opentelemetry-util-http
@@ -161,7 +156,6 @@ setenv =
   ; i.e: CONTRIB_REPO_SHA=dde62cebffe519c35875af6d06fae053b3be65ec tox -e <env to test>
   CONTRIB_REPO_SHA={env:CONTRIB_REPO_SHA:main}
   CONTRIB_REPO=git+https://github.com/open-telemetry/opentelemetry-python-contrib.git@{env:CONTRIB_REPO_SHA}
-  mypy: MYPYPATH={toxinidir}/opentelemetry-api/src/:{toxinidir}/opentelemetry-semantic-conventions/src/:{toxinidir}/opentelemetry-sdk/src/:{toxinidir}/tests/opentelemetry-test-utils/src/
 commands_pre =
   ; In order to get a healthy coverage report,
   ; we have to install packages in editable mode.
@@ -230,18 +224,6 @@ commands =
 
   coverage: {toxinidir}/scripts/coverage.sh
 
-  mypy: mypy --version
-  mypy: mypy --install-types --non-interactive --namespace-packages --explicit-package-bases opentelemetry-api/src/opentelemetry/
-  mypy: mypy --install-types --non-interactive --namespace-packages --explicit-package-bases opentelemetry-sdk/src/opentelemetry/sdk/resources
-  mypy: mypy --install-types --non-interactive --namespace-packages --explicit-package-bases opentelemetry-semantic-conventions/src/opentelemetry/semconv/
-
-  ; For test code, we don't want to enforce the full mypy strictness
-  mypy: mypy --install-types --non-interactive --namespace-packages --config-file=mypy-relaxed.ini opentelemetry-api/tests/
-
-  ; Test that mypy can pick up typeinfo from an installed package (otherwise,
-  ; implicit Any due to unfollowed import would result).
-  mypyinstalled: mypy --install-types --non-interactive --namespace-packages opentelemetry-api/tests/mypysmoke.py --strict
-
 [testenv:spellcheck]
 basepython: python3
 recreate = True