diff --git a/.github/workflows/awstest.yml b/.github/workflows/awstest.yml
index e687dc5056..6ae1c5b8a8 100644
--- a/.github/workflows/awstest.yml
+++ b/.github/workflows/awstest.yml
@@ -23,79 +23,39 @@ on:
 jobs:
   trigger-profile-test:
     name: Run AWS tests
-    if: ( github.repository == 'nf-core/sarek' ) && ( github.event_name != 'workflow_dispatch' || inputs.profiletest )
     runs-on: ubuntu-latest
+    strategy:
+      fail-fast: false
+      matrix:
+        include:
+          - profile: test
+            enabled: ${{ ( github.repository == 'nf-core/sarek' ) && ( github.event_name != 'workflow_dispatch' || inputs.profiletest ) }}
+          - profile: test_full
+            enabled: ${{ ( github.repository == 'nf-core/sarek' ) && ( github.event_name != 'workflow_dispatch' || inputs.somatic ) }}
+          - profile: test_full_germline
+            enabled: ${{ ( github.repository == 'nf-core/sarek' ) && ( github.event_name != 'workflow_dispatch' || inputs.germline ) }}
     steps:
       # Launch workflow using Tower CLI tool action
       - name: Launch workflow via tower
         uses: seqeralabs/action-tower-launch@v2
+        if: ${{ matrix.enabled }}
         with:
           workspace_id: ${{ secrets.TOWER_WORKSPACE_ID }}
           access_token: ${{ secrets.TOWER_ACCESS_TOKEN }}
           compute_env: ${{ secrets.TOWER_COMPUTE_ENV }}
           revision: ${{ github.sha }}
-          workdir: s3://${{ secrets.AWS_S3_BUCKET }}/work/sarek/work-${{ github.sha }}
-          parameters: |
-            {
-              "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/sarek/results-test-${{ github.sha }}"
-            }
-          profiles: test
-      - uses: actions/upload-artifact@v3
-        with:
-          name: tower-profiletest-log
-          path: |
-            tower_action_*.log
-            tower_action_*.json
-
-  trigger-full-test-somatic:
-    name: Run AWS full tests
-    if: ${{ ( github.repository == 'nf-core/sarek' ) && ( github.event_name != 'workflow_dispatch' || inputs.somatic ) }}
-    runs-on: ubuntu-latest
-    steps:
-      # Launch workflow using Tower CLI tool action
-      - name: Launch workflow via tower
-        uses: seqeralabs/action-tower-launch@v2
-        with:
-          workspace_id: ${{ secrets.TOWER_WORKSPACE_ID }}
-          access_token: ${{ secrets.TOWER_ACCESS_TOKEN }}
-          compute_env: ${{ secrets.TOWER_COMPUTE_ENV }}
-          revision: ${{ github.sha }}
-          workdir: s3://${{ secrets.AWS_S3_BUCKET }}/work/sarek/work-${{ github.sha }}/somatic_test
+          workdir: s3://${{ secrets.AWS_S3_BUCKET }}/work/sarek/work-${{ github.sha }}/${{ matrix.profile }}
           parameters: |
             {
               "hook_url": "${{ secrets.MEGATESTS_ALERTS_SLACK_HOOK_URL }}",
-              "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/sarek/results-${{ github.sha }}/somatic_test"
+              "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/sarek/results-test-${{ github.sha }}/${{ matrix.profile }}"
             }
-          profiles: test_full
+          profiles: ${{ matrix.profile }}
 
       - uses: actions/upload-artifact@v3
+        if: ${{ matrix.enabled }}
         with:
-          name: tower-full-somatic-log
+          name: tower-${{ matrix.profile }}-log
           path: |
             tower_action_*.log
             tower_action_*.json
-
-  trigger-full-test-germline:
-    name: Run AWS full tests
-    if: ${{ ( github.repository == 'nf-core/sarek' ) && ( github.event_name != 'workflow_dispatch' || inputs.germline ) }}
-    runs-on: ubuntu-latest
-    steps:
-      # Launch workflow using Tower CLI tool action
-      - name: Launch workflow via tower
-        uses: seqeralabs/action-tower-launch@v2
-        with:
-          workspace_id: ${{ secrets.TOWER_WORKSPACE_ID }}
-          access_token: ${{ secrets.TOWER_ACCESS_TOKEN }}
-          compute_env: ${{ secrets.TOWER_COMPUTE_ENV }}
-          revision: ${{ github.sha }}
-          workdir: s3://${{ secrets.AWS_S3_BUCKET }}/work/sarek/work-${{ github.sha }}/germline_test
-          parameters: |
-            {
-              "hook_url": "${{ secrets.MEGATESTS_ALERTS_SLACK_HOOK_URL }}",
-              "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/sarek/results-${{ github.sha }}/germline_test"
-            }
-          profiles: test_full_germline
-      - uses: actions/upload-artifact@v3
-        with:
-          name: tower-full-germline-log
-          path: tower_action_*.log
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 539b938e1b..65bf5219aa 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -34,6 +34,7 @@ Rapaselet is a delta formed by the Rapaätno river between the Bielloriehppe mas
 - [#1180](https://github.com/nf-core/sarek/pull/1180) - Updating the nf-core modules
 - [#1198](https://github.com/nf-core/sarek/pull/1198) - Prepare release `3.3.0`
 - [#1200](https://github.com/nf-core/sarek/pull/1200) - Streamline Github Actions workflows
+- [#1212](https://github.com/nf-core/sarek/pull/1212) - Use matrix for AWS megatests
 
 ### Fixed