diff --git a/packages/jest-react/src/JestReact.js b/packages/jest-react/src/JestReact.js
index b4688f1ff980a..92f7e7cdb192d 100644
--- a/packages/jest-react/src/JestReact.js
+++ b/packages/jest-react/src/JestReact.js
@@ -7,7 +7,6 @@
 
 import {REACT_ELEMENT_TYPE, REACT_FRAGMENT_TYPE} from 'shared/ReactSymbols';
 
-import invariant from 'shared/invariant';
 import isArray from 'shared/isArray';
 
 export {act} from './internalAct';
@@ -31,11 +30,12 @@ function captureAssertion(fn) {
 function assertYieldsWereCleared(root) {
   const Scheduler = root._Scheduler;
   const actualYields = Scheduler.unstable_clearYields();
-  invariant(
-    actualYields.length === 0,
-    'Log of yielded values is not empty. ' +
-      'Call expect(ReactTestRenderer).unstable_toHaveYielded(...) first.',
-  );
+  if (actualYields.length !== 0) {
+    throw new Error(
+      'Log of yielded values is not empty. ' +
+        'Call expect(ReactTestRenderer).unstable_toHaveYielded(...) first.',
+    );
+  }
 }
 
 export function unstable_toMatchRenderedOutput(root, expectedJSX) {
diff --git a/packages/react-reconciler/src/ReactFiberThrow.new.js b/packages/react-reconciler/src/ReactFiberThrow.new.js
index 78e88f125a1aa..85728d96bb730 100644
--- a/packages/react-reconciler/src/ReactFiberThrow.new.js
+++ b/packages/react-reconciler/src/ReactFiberThrow.new.js
@@ -474,7 +474,8 @@ function throwException(
       return;
     } else {
       // No boundary was found. Fallthrough to error mode.
-      // TODO: Use invariant so the message is stripped in prod?
+      // TODO: We should never call getComponentNameFromFiber in production.
+      // Log a warning or something to prevent us from accidentally bundling it.
       value = new Error(
         (getComponentNameFromFiber(sourceFiber) || 'A React component') +
           ' suspended while rendering, but no fallback UI was specified.\n' +
diff --git a/packages/react-reconciler/src/ReactFiberThrow.old.js b/packages/react-reconciler/src/ReactFiberThrow.old.js
index d2d39793a3bc0..27b0719ba8532 100644
--- a/packages/react-reconciler/src/ReactFiberThrow.old.js
+++ b/packages/react-reconciler/src/ReactFiberThrow.old.js
@@ -474,7 +474,8 @@ function throwException(
       return;
     } else {
       // No boundary was found. Fallthrough to error mode.
-      // TODO: Use invariant so the message is stripped in prod?
+      // TODO: We should never call getComponentNameFromFiber in production.
+      // Log a warning or something to prevent us from accidentally bundling it.
       value = new Error(
         (getComponentNameFromFiber(sourceFiber) || 'A React component') +
           ' suspended while rendering, but no fallback UI was specified.\n' +
diff --git a/scripts/error-codes/__tests__/__snapshots__/transform-error-messages.js.snap b/scripts/error-codes/__tests__/__snapshots__/transform-error-messages.js.snap
index f93b31a659dd2..bfb80ab375562 100644
--- a/scripts/error-codes/__tests__/__snapshots__/transform-error-messages.js.snap
+++ b/scripts/error-codes/__tests__/__snapshots__/transform-error-messages.js.snap
@@ -1,5 +1,10 @@
 // Jest Snapshot v1, https://goo.gl/fbAQLP
 
+exports[`error transform handles escaped backticks in template string 1`] = `
+"import _formatProdErrorMessage from \\"shared/formatProdErrorMessage\\";
+Error(__DEV__ ? \\"Expected \`\\" + listener + \\"\` listener to be a function, instead got a value of \`\\" + type + \\"\` type.\\" : _formatProdErrorMessage(231, listener, type));"
+`;
+
 exports[`error transform should correctly transform invariants that are not in the error codes map 1`] = `
 "import invariant from 'shared/invariant';
 
@@ -18,6 +23,21 @@ if (!condition) {
 }"
 `;
 
+exports[`error transform should not touch other calls or new expressions 1`] = `
+"new NotAnError();
+NotAnError();"
+`;
+
+exports[`error transform should replace error constructors (no new) 1`] = `
+"import _formatProdErrorMessage from \\"shared/formatProdErrorMessage\\";
+Error(__DEV__ ? 'Do not override existing functions.' : _formatProdErrorMessage(16));"
+`;
+
+exports[`error transform should replace error constructors 1`] = `
+"import _formatProdErrorMessage from \\"shared/formatProdErrorMessage\\";
+Error(__DEV__ ? 'Do not override existing functions.' : _formatProdErrorMessage(16));"
+`;
+
 exports[`error transform should replace simple invariant calls 1`] = `
 "import _formatProdErrorMessage from \\"shared/formatProdErrorMessage\\";
 import invariant from 'shared/invariant';
@@ -29,6 +49,21 @@ if (!condition) {
 }"
 `;
 
+exports[`error transform should support error constructors with concatenated messages 1`] = `
+"import _formatProdErrorMessage from \\"shared/formatProdErrorMessage\\";
+Error(__DEV__ ? \\"Expected \\" + foo + \\" target to \\" + (\\"be an array; got \\" + bar) : _formatProdErrorMessage(7, foo, bar));"
+`;
+
+exports[`error transform should support interpolating arguments with concatenation 1`] = `
+"import _formatProdErrorMessage from \\"shared/formatProdErrorMessage\\";
+Error(__DEV__ ? 'Expected ' + foo + ' target to be an array; got ' + bar : _formatProdErrorMessage(7, foo, bar));"
+`;
+
+exports[`error transform should support interpolating arguments with template strings 1`] = `
+"import _formatProdErrorMessage from \\"shared/formatProdErrorMessage\\";
+Error(__DEV__ ? \\"Expected \\" + foo + \\" target to be an array; got \\" + bar : _formatProdErrorMessage(7, foo, bar));"
+`;
+
 exports[`error transform should support invariant calls with a concatenated template string and args 1`] = `
 "import _formatProdErrorMessage from \\"shared/formatProdErrorMessage\\";
 import invariant from 'shared/invariant';
diff --git a/scripts/error-codes/__tests__/transform-error-messages.js b/scripts/error-codes/__tests__/transform-error-messages.js
index 4da00ac656b95..2bca7366321e2 100644
--- a/scripts/error-codes/__tests__/transform-error-messages.js
+++ b/scripts/error-codes/__tests__/transform-error-messages.js
@@ -93,4 +93,61 @@ invariant(condition, 'Do not override existing functions.');
       )
     ).toMatchSnapshot();
   });
+
+  it('should replace error constructors', () => {
+    expect(
+      transform(`
+new Error('Do not override existing functions.');
+`)
+    ).toMatchSnapshot();
+  });
+
+  it('should replace error constructors (no new)', () => {
+    expect(
+      transform(`
+Error('Do not override existing functions.');
+`)
+    ).toMatchSnapshot();
+  });
+
+  it('should not touch other calls or new expressions', () => {
+    expect(
+      transform(`
+new NotAnError();
+NotAnError();
+`)
+    ).toMatchSnapshot();
+  });
+
+  it('should support interpolating arguments with template strings', () => {
+    expect(
+      transform(`
+new Error(\`Expected \${foo} target to be an array; got \${bar}\`);
+`)
+    ).toMatchSnapshot();
+  });
+
+  it('should support interpolating arguments with concatenation', () => {
+    expect(
+      transform(`
+new Error('Expected ' + foo + ' target to be an array; got ' + bar);
+`)
+    ).toMatchSnapshot();
+  });
+
+  it('should support error constructors with concatenated messages', () => {
+    expect(
+      transform(`
+new Error(\`Expected \${foo} target to \` + \`be an array; got \${bar}\`);
+`)
+    ).toMatchSnapshot();
+  });
+
+  it('handles escaped backticks in template string', () => {
+    expect(
+      transform(`
+new Error(\`Expected \\\`\$\{listener\}\\\` listener to be a function, instead got a value of \\\`\$\{type\}\\\` type.\`);
+`)
+    ).toMatchSnapshot();
+  });
 });
diff --git a/scripts/error-codes/codes.json b/scripts/error-codes/codes.json
index 3206efa41349c..2c5263a8ff141 100644
--- a/scripts/error-codes/codes.json
+++ b/scripts/error-codes/codes.json
@@ -287,12 +287,10 @@
   "288": "It is not supported to run the profiling version of a renderer (for example, `react-dom/profiling`) without also replacing the `schedule/tracing` module with `schedule/tracing-profiling`. Your bundler might have a setting for aliasing both modules. Learn more at https://reactjs.org/link/profiling",
   "289": "Function components cannot have refs.",
   "290": "Element ref was specified as a string (%s) but no owner was set. This could happen for one of the following reasons:\n1. You may be adding a ref to a function component\n2. You may be adding a ref to a component that was not created inside a component's render method\n3. You have multiple copies of React loaded\nSee https://reactjs.org/link/refs-must-have-owner for more information.",
-  "291": "Log of yielded values is not empty. Call expect(Scheduler).toHaveYielded(...) first.",
   "292": "The matcher `toHaveYielded` expects an instance of React Test Renderer.\n\nTry: expect(Scheduler).toHaveYielded(expectedYields)",
   "293": "Context can only be read while React is rendering, e.g. inside the render method or getDerivedStateFromProps.",
   "294": "ReactDOMServer does not yet support Suspense.",
   "295": "ReactDOMServer does not yet support lazy-loaded components.",
-  "296": "Log of yielded values is not empty. Call expect(ReactTestRenderer).unstable_toHaveYielded(...) first.",
   "297": "The matcher `unstable_toHaveYielded` expects an instance of React Test Renderer.\n\nTry: expect(ReactTestRenderer).unstable_toHaveYielded(expectedYields)",
   "298": "Hooks can only be called inside the body of a function component.",
   "299": "createRoot(...): Target container is not a DOM element.",
@@ -397,5 +395,6 @@
   "406": "act(...) is not supported in production builds of React.",
   "407": "Missing getServerSnapshot, which is required for server-rendered content. Will revert to client rendering.",
   "408": "Missing getServerSnapshot, which is required for server-rendered content.",
-  "409": "Cannot update an unmounted root."
+  "409": "Cannot update an unmounted root.",
+  "410": "%s suspended while rendering, but no fallback UI was specified.\n\nAdd a <Suspense fallback=...> component higher in the tree to provide a loading indicator or placeholder to display."
 }
diff --git a/scripts/error-codes/extract-errors.js b/scripts/error-codes/extract-errors.js
index 58823cbe16873..d60ffe308cdbe 100644
--- a/scripts/error-codes/extract-errors.js
+++ b/scripts/error-codes/extract-errors.js
@@ -10,7 +10,7 @@ const parser = require('@babel/parser');
 const fs = require('fs');
 const path = require('path');
 const traverse = require('@babel/traverse').default;
-const evalToString = require('../shared/evalToString');
+const {evalStringConcat} = require('../shared/evalToString');
 const invertObject = require('./invertObject');
 
 const babylonOptions = {
@@ -75,7 +75,7 @@ module.exports = function(opts) {
 
             // error messages can be concatenated (`+`) at runtime, so here's a
             // trivial partial evaluator that interprets the literal value
-            const errorMsgLiteral = evalToString(node.arguments[1]);
+            const errorMsgLiteral = evalStringConcat(node.arguments[1]);
             addToErrorMap(errorMsgLiteral);
           }
         },
diff --git a/scripts/error-codes/transform-error-messages.js b/scripts/error-codes/transform-error-messages.js
index 6ebb68731f860..2baf4baa1c1a7 100644
--- a/scripts/error-codes/transform-error-messages.js
+++ b/scripts/error-codes/transform-error-messages.js
@@ -7,20 +7,114 @@
 'use strict';
 
 const fs = require('fs');
-const evalToString = require('../shared/evalToString');
+const {
+  evalStringConcat,
+  evalStringAndTemplateConcat,
+} = require('../shared/evalToString');
 const invertObject = require('./invertObject');
 const helperModuleImports = require('@babel/helper-module-imports');
 
+const errorMap = invertObject(
+  JSON.parse(fs.readFileSync(__dirname + '/codes.json', 'utf-8'))
+);
+
+const SEEN_SYMBOL = Symbol('transform-error-messages.seen');
+
 module.exports = function(babel) {
   const t = babel.types;
 
+  // TODO: Instead of outputting __DEV__ conditions, only apply this transform
+  // in production.
   const DEV_EXPRESSION = t.identifier('__DEV__');
 
+  function CallOrNewExpression(path, file) {
+    // Turns this code:
+    //
+    // new Error(`A ${adj} message that contains ${noun}`);
+    //
+    // or this code (no constructor):
+    //
+    // Error(`A ${adj} message that contains ${noun}`);
+    //
+    // into this:
+    //
+    // Error(
+    //   __DEV__
+    //     ? `A ${adj} message that contains ${noun}`
+    //     : formatProdErrorMessage(ERR_CODE, adj, noun)
+    // );
+    const node = path.node;
+    if (node[SEEN_SYMBOL]) {
+      return;
+    }
+    node[SEEN_SYMBOL] = true;
+
+    const errorMsgNode = node.arguments[0];
+    if (errorMsgNode === undefined) {
+      return;
+    }
+
+    const errorMsgExpressions = [];
+    const errorMsgLiteral = evalStringAndTemplateConcat(
+      errorMsgNode,
+      errorMsgExpressions
+    );
+
+    let prodErrorId = errorMap[errorMsgLiteral];
+    if (prodErrorId === undefined) {
+      // There is no error code for this message. We use a lint rule to
+      // enforce that messages can be minified, so assume this is
+      // intentional and exit gracefully.
+      return;
+    }
+    prodErrorId = parseInt(prodErrorId, 10);
+
+    // Import formatProdErrorMessage
+    const formatProdErrorMessageIdentifier = helperModuleImports.addDefault(
+      path,
+      'shared/formatProdErrorMessage',
+      {nameHint: 'formatProdErrorMessage'}
+    );
+
+    // Outputs:
+    //   formatProdErrorMessage(ERR_CODE, adj, noun);
+    const prodMessage = t.callExpression(formatProdErrorMessageIdentifier, [
+      t.numericLiteral(prodErrorId),
+      ...errorMsgExpressions,
+    ]);
+
+    // Outputs:
+    // Error(
+    //   __DEV__
+    //     ? `A ${adj} message that contains ${noun}`
+    //     : formatProdErrorMessage(ERR_CODE, adj, noun)
+    // );
+    path.replaceWith(t.callExpression(t.identifier('Error'), [prodMessage]));
+    path.replaceWith(
+      t.callExpression(t.identifier('Error'), [
+        t.conditionalExpression(DEV_EXPRESSION, errorMsgNode, prodMessage),
+      ])
+    );
+  }
+
   return {
     visitor: {
+      NewExpression(path, file) {
+        const noMinify = file.opts.noMinify;
+        if (!noMinify && path.get('callee').isIdentifier({name: 'Error'})) {
+          CallOrNewExpression(path, file);
+        }
+      },
+
       CallExpression(path, file) {
         const node = path.node;
         const noMinify = file.opts.noMinify;
+
+        if (!noMinify && path.get('callee').isIdentifier({name: 'Error'})) {
+          CallOrNewExpression(path, file);
+          return;
+        }
+
         if (path.get('callee').isIdentifier({name: 'invariant'})) {
           // Turns this code:
           //
@@ -40,7 +134,7 @@ module.exports = function(babel) {
           // string) that references a verbose error message. The mapping is
           // stored in `scripts/error-codes/codes.json`.
           const condition = node.arguments[0];
-          const errorMsgLiteral = evalToString(node.arguments[1]);
+          const errorMsgLiteral = evalStringConcat(node.arguments[1]);
           const errorMsgExpressions = Array.from(node.arguments.slice(2));
           const errorMsgQuasis = errorMsgLiteral
             .split('%s')
@@ -81,12 +175,6 @@ module.exports = function(babel) {
             return;
           }
 
-          // Avoid caching because we write it as we go.
-          const existingErrorMap = JSON.parse(
-            fs.readFileSync(__dirname + '/codes.json', 'utf-8')
-          );
-          const errorMap = invertObject(existingErrorMap);
-
           let prodErrorId = errorMap[errorMsgLiteral];
 
           if (prodErrorId === undefined) {
@@ -117,7 +205,7 @@ module.exports = function(babel) {
           }
           prodErrorId = parseInt(prodErrorId, 10);
 
-          // Import ReactErrorProd
+          // Import formatProdErrorMessage
           const formatProdErrorMessageIdentifier = helperModuleImports.addDefault(
             path,
             'shared/formatProdErrorMessage',
diff --git a/scripts/print-warnings/print-warnings.js b/scripts/print-warnings/print-warnings.js
index 9bdd6543d2a3d..8e23dd880e92b 100644
--- a/scripts/print-warnings/print-warnings.js
+++ b/scripts/print-warnings/print-warnings.js
@@ -12,7 +12,7 @@ const through = require('through2');
 const traverse = require('@babel/traverse').default;
 const gs = require('glob-stream');
 
-const evalToString = require('../shared/evalToString');
+const {evalStringConcat} = require('../shared/evalToString');
 
 const parserOptions = {
   sourceType: 'module',
@@ -64,7 +64,7 @@ function transform(file, enc, cb) {
             // warning messages can be concatenated (`+`) at runtime, so here's
             // a trivial partial evaluator that interprets the literal value
             try {
-              const warningMsgLiteral = evalToString(node.arguments[0]);
+              const warningMsgLiteral = evalStringConcat(node.arguments[0]);
               warnings.add(JSON.stringify(warningMsgLiteral));
             } catch (error) {
               console.error(
diff --git a/scripts/shared/__tests__/evalToString-test.js b/scripts/shared/__tests__/evalToString-test.js
index 3f6c3adbb372a..bc0cb600d57e4 100644
--- a/scripts/shared/__tests__/evalToString-test.js
+++ b/scripts/shared/__tests__/evalToString-test.js
@@ -6,12 +6,12 @@
  */
 'use strict';
 
-const evalToString = require('../evalToString');
+const {evalStringConcat} = require('../evalToString');
 const parser = require('@babel/parser');
 
 const parse = source => parser.parse(`(${source});`).program.body[0].expression; // quick way to get an exp node
 
-const parseAndEval = source => evalToString(parse(source));
+const parseAndEval = source => evalStringConcat(parse(source));
 
 describe('evalToString', () => {
   it('should support StringLiteral', () => {
diff --git a/scripts/shared/evalToString.js b/scripts/shared/evalToString.js
index aad199da5d75b..318925cc0969e 100644
--- a/scripts/shared/evalToString.js
+++ b/scripts/shared/evalToString.js
@@ -8,7 +8,7 @@
  */
 'use strict';
 
-function evalToString(ast /* : Object */) /* : string */ {
+function evalStringConcat(ast /* : Object */) /* : string */ {
   switch (ast.type) {
     case 'StringLiteral':
     case 'Literal': // ESLint
@@ -17,10 +17,44 @@ function evalToString(ast /* : Object */) /* : string */ {
       if (ast.operator !== '+') {
         throw new Error('Unsupported binary operator ' + ast.operator);
       }
-      return evalToString(ast.left) + evalToString(ast.right);
+      return evalStringConcat(ast.left) + evalStringConcat(ast.right);
     default:
       throw new Error('Unsupported type ' + ast.type);
   }
 }
+exports.evalStringConcat = evalStringConcat;
 
-module.exports = evalToString;
+function evalStringAndTemplateConcat(
+  ast /* : Object */,
+  args /* : Array<mixed> */
+) /* : string */ {
+  switch (ast.type) {
+    case 'StringLiteral':
+      return ast.value;
+    case 'BinaryExpression': // `+`
+      if (ast.operator !== '+') {
+        throw new Error('Unsupported binary operator ' + ast.operator);
+      }
+      return (
+        evalStringAndTemplateConcat(ast.left, args) +
+        evalStringAndTemplateConcat(ast.right, args)
+      );
+    case 'TemplateLiteral': {
+      let elements = [];
+      for (let i = 0; i < ast.quasis.length; i++) {
+        const elementNode = ast.quasis[i];
+        if (elementNode.type !== 'TemplateElement') {
+          throw new Error('Unsupported type ' + ast.type);
+        }
+        elements.push(elementNode.value.cooked);
+      }
+      args.push(...ast.expressions);
+      return elements.join('%s');
+    }
+    default:
+      // Anything that's not a string is interpreted as an argument.
+      args.push(ast);
+      return '%s';
+  }
+}
+exports.evalStringAndTemplateConcat = evalStringAndTemplateConcat;