diff --git a/fixtures/attribute-behavior/AttributeTableSnapshot.md b/fixtures/attribute-behavior/AttributeTableSnapshot.md
index c924b215355dd..d57643bd44b42 100644
--- a/fixtures/attribute-behavior/AttributeTableSnapshot.md
+++ b/fixtures/attribute-behavior/AttributeTableSnapshot.md
@@ -2773,6 +2773,31 @@
 | `disabled=(null)`| (initial)| `<boolean: false>` |
 | `disabled=(undefined)`| (initial)| `<boolean: false>` |
 
+## `disablePictureInPicture` (on `<video>` inside `<div>`)
+| Test Case | Flags | Result |
+| -disablePictureInPicture | --- |
+| `disablePictureInPicture=(string)`| (changed)| `<boolean: true>` |
+| `disablePictureInPicture=(empty string)`| (initial)| `<boolean: false>` |
+| `disablePictureInPicture=(array with string)`| (changed)| `<boolean: true>` |
+| `disablePictureInPicture=(empty array)`| (changed)| `<boolean: true>` |
+| `disablePictureInPicture=(object)`| (changed)| `<boolean: true>` |
+| `disablePictureInPicture=(numeric string)`| (changed)| `<boolean: true>` |
+| `disablePictureInPicture=(-1)`| (changed)| `<boolean: true>` |
+| `disablePictureInPicture=(0)`| (initial)| `<boolean: false>` |
+| `disablePictureInPicture=(integer)`| (changed)| `<boolean: true>` |
+| `disablePictureInPicture=(NaN)`| (initial, warning)| `<boolean: false>` |
+| `disablePictureInPicture=(float)`| (changed)| `<boolean: true>` |
+| `disablePictureInPicture=(true)`| (changed)| `<boolean: true>` |
+| `disablePictureInPicture=(false)`| (initial)| `<boolean: false>` |
+| `disablePictureInPicture=(string 'true')`| (changed, warning)| `<boolean: true>` |
+| `disablePictureInPicture=(string 'false')`| (changed, warning)| `<boolean: true>` |
+| `disablePictureInPicture=(string 'on')`| (changed)| `<boolean: true>` |
+| `disablePictureInPicture=(string 'off')`| (changed)| `<boolean: true>` |
+| `disablePictureInPicture=(symbol)`| (initial, warning)| `<boolean: false>` |
+| `disablePictureInPicture=(function)`| (initial, warning)| `<boolean: false>` |
+| `disablePictureInPicture=(null)`| (initial)| `<boolean: false>` |
+| `disablePictureInPicture=(undefined)`| (initial)| `<boolean: false>` |
+
 ## `display` (on `<svg>` inside `<div>`)
 | Test Case | Flags | Result |
 | --- | --- | --- |
diff --git a/fixtures/attribute-behavior/src/attributes.js b/fixtures/attribute-behavior/src/attributes.js
index b0f25c10f4edb..a7f5b5e617784 100644
--- a/fixtures/attribute-behavior/src/attributes.js
+++ b/fixtures/attribute-behavior/src/attributes.js
@@ -448,6 +448,7 @@ const attributes = [
     read: getSVGAttribute('direction'),
   },
   {name: 'disabled', tagName: 'input'},
+  {name: 'disablePictureInPicture', tagName: 'video'},
   {
     name: 'display',
     tagName: 'svg',
diff --git a/packages/react-dom/src/shared/DOMProperty.js b/packages/react-dom/src/shared/DOMProperty.js
index e770e0f722cc8..bdfa10e14aacf 100644
--- a/packages/react-dom/src/shared/DOMProperty.js
+++ b/packages/react-dom/src/shared/DOMProperty.js
@@ -294,6 +294,7 @@ const properties = {};
   'default',
   'defer',
   'disabled',
+  'disablePictureInPicture',
   'formNoValidate',
   'hidden',
   'loop',
diff --git a/packages/react-dom/src/shared/possibleStandardNames.js b/packages/react-dom/src/shared/possibleStandardNames.js
index ec7f6a6c58b8b..81ab686405c89 100644
--- a/packages/react-dom/src/shared/possibleStandardNames.js
+++ b/packages/react-dom/src/shared/possibleStandardNames.js
@@ -54,6 +54,7 @@ const possibleStandardNames = {
   defer: 'defer',
   dir: 'dir',
   disabled: 'disabled',
+  disablePictureInPicture: 'disablePictureInPicture',
   download: 'download',
   draggable: 'draggable',
   enctype: 'encType',