diff --git a/src/preamble.js b/src/preamble.js
index 042bb0e9c80f1..9c7baffb7c0fa 100644
--- a/src/preamble.js
+++ b/src/preamble.js
@@ -1120,6 +1120,24 @@ function createWasm() {
       var exports = Module['instantiateWasm'](info, receiveInstance);
 #if ASYNCIFY
       exports = Asyncify.instrumentWasmExports(exports);
+#endif
+#if USE_OFFSET_CONVERTER
+      {{{
+        runOnMainThread(`
+          // We have no way to create an OffsetConverter in this code path since
+          // we have no access to the wasm binary (only the user does). Instead,
+          // create a fake one that reports we cannot identify functions from
+          // their binary offsets.
+          // Note that we only do this on the main thread, as the workers
+          // receive the OffsetConverter data from there.
+          wasmOffsetConverter = {
+            getName: function() {
+              return 'unknown-due-to-instantiateWasm';
+            }
+          };
+          removeRunDependency('offset-converter');
+        `)
+      }}}
 #endif
       return exports;
     } catch(e) {
diff --git a/tests/test_browser.py b/tests/test_browser.py
index bbdf840469ee1..555ea8bc3a50f 100644
--- a/tests/test_browser.py
+++ b/tests/test_browser.py
@@ -4155,8 +4155,12 @@ def test_binaryen_async(self):
     self.btest_exit('binaryen_async.c', expected=1, args=common_args)
 
   # Test that implementing Module.instantiateWasm() callback works.
-  def test_manual_wasm_instantiate(self):
-    self.compile_btest([path_from_root('tests/manual_wasm_instantiate.cpp'), '-o', 'manual_wasm_instantiate.js', '-s', 'BINARYEN'])
+  @parameterized({
+    '': ([],),
+    'asan': (['-fsanitize=address', '-s', 'INITIAL_MEMORY=128MB'],)
+  })
+  def test_manual_wasm_instantiate(self, args=[]):
+    self.compile_btest([path_from_root('tests/manual_wasm_instantiate.cpp'), '-o', 'manual_wasm_instantiate.js'] + args)
     shutil.copyfile(path_from_root('tests', 'manual_wasm_instantiate.html'), 'manual_wasm_instantiate.html')
     self.run_browser('manual_wasm_instantiate.html', 'wasm instantiation succeeded', '/report_result?1')