diff --git a/lib/instrumentation/modules/mysql2.js b/lib/instrumentation/modules/mysql2.js
index b75d663b03..46f031fb23 100644
--- a/lib/instrumentation/modules/mysql2.js
+++ b/lib/instrumentation/modules/mysql2.js
@@ -27,8 +27,22 @@ module.exports = function (mysql2, agent, { version, enabled }) {
 
   var ins = agent._instrumentation;
 
-  shimmer.wrap(mysql2.Connection.prototype, 'query', wrapQuery);
-  shimmer.wrap(mysql2.Connection.prototype, 'execute', wrapQuery);
+  // mysql2@3.11.5 added BaseConnection class which is extended by Connection
+  // but is not in the public API so we need to extract it via prototype chain
+  // ref: https://github.com/sidorares/node-mysql2/pull/3081
+  const baseClass = Object.getPrototypeOf(mysql2.Connection);
+  const baseProto = baseClass.prototype;
+  const hasQuery = typeof baseProto?.query === 'function';
+  const hasExec = typeof baseProto?.execute === 'function';
+  const shouldPatchBase = hasQuery && hasExec;
+
+  if (shouldPatchBase) {
+    shimmer.wrap(baseProto, 'query', wrapQuery);
+    shimmer.wrap(baseProto, 'execute', wrapQuery);
+  } else {
+    shimmer.wrap(mysql2.Connection.prototype, 'query', wrapQuery);
+    shimmer.wrap(mysql2.Connection.prototype, 'execute', wrapQuery);
+  }
 
   return mysql2;
 
diff --git a/package-lock.json b/package-lock.json
index 889d9317ba..f8f3b669c9 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -12581,9 +12581,9 @@
       }
     },
     "node_modules/mysql2": {
-      "version": "3.11.4",
-      "resolved": "https://registry.npmjs.org/mysql2/-/mysql2-3.11.4.tgz",
-      "integrity": "sha512-Z2o3tY4Z8EvSRDwknaC40MdZ3+m0sKbpnXrShQLdxPrAvcNli7jLrD2Zd2IzsRMw4eK9Yle500FDmlkIqp+krg==",
+      "version": "3.11.5",
+      "resolved": "https://registry.npmjs.org/mysql2/-/mysql2-3.11.5.tgz",
+      "integrity": "sha512-0XFu8rUmFN9vC0ME36iBvCUObftiMHItrYFhlCRvFWbLgpNqtC4Br/NmZX1HNCszxT0GGy5QtP+k3Q3eCJPaYA==",
       "dev": true,
       "dependencies": {
         "aws-ssl-profiles": "^1.1.1",
@@ -26168,9 +26168,9 @@
       }
     },
     "mysql2": {
-      "version": "3.11.4",
-      "resolved": "https://registry.npmjs.org/mysql2/-/mysql2-3.11.4.tgz",
-      "integrity": "sha512-Z2o3tY4Z8EvSRDwknaC40MdZ3+m0sKbpnXrShQLdxPrAvcNli7jLrD2Zd2IzsRMw4eK9Yle500FDmlkIqp+krg==",
+      "version": "3.11.5",
+      "resolved": "https://registry.npmjs.org/mysql2/-/mysql2-3.11.5.tgz",
+      "integrity": "sha512-0XFu8rUmFN9vC0ME36iBvCUObftiMHItrYFhlCRvFWbLgpNqtC4Br/NmZX1HNCszxT0GGy5QtP+k3Q3eCJPaYA==",
       "dev": true,
       "requires": {
         "aws-ssl-profiles": "^1.1.1",