diff --git a/.bazelrc b/.bazelrc
index 61eb2820d3f..c0076b69301 100644
--- a/.bazelrc
+++ b/.bazelrc
@@ -137,6 +137,9 @@ build:benchmark --config=profile
 
 # Define a debug config which is primarily intended for local development.
 build:debug -c dbg
+build:debug --copt=-DDEBUG --copt=-UNDEBUG
+# Set rust-debug to limit excessive debug info for Rust
+build:debug --config=rust-debug
 
 # Using simple template names saves around 5% of binary size of workerd.
 build:unix --cxxopt='-gsimple-template-names' --host_cxxopt='-gsimple-template-names'
@@ -185,6 +188,8 @@ build:thin-lto --@rules_rust//:extra_rustc_flag=-Ccodegen-units=1
 build:sanitizer-common --@workerd//src/workerd/server:use_tcmalloc=False
 build:sanitizer-common --copt="-fsanitize-link-c++-runtime" --linkopt="-fsanitize-link-c++-runtime"
 build:sanitizer-common --copt="-Og"
+build:sanitizer-common --@rules_rust//:extra_rustc_flag=-Copt-level=1
+build:sanitizer-common --config=rust-debug
 build:sanitizer-common --copt="-g" --strip=never
 build:sanitizer-common --copt="-fno-optimize-sibling-calls"
 build:sanitizer-common --copt="-fno-omit-frame-pointer" --copt="-mno-omit-leaf-frame-pointer"
diff --git a/build/ci.bazelrc b/build/ci.bazelrc
index 53eab9d8231..280cd6804cd 100644
--- a/build/ci.bazelrc
+++ b/build/ci.bazelrc
@@ -66,14 +66,14 @@ build:ci-linux --config=ci-linux-common --config=ci-limit-storage --remote_downl
 build:ci-linux-arm --config=ci-linux-common --config=ci-limit-storage
 
 build:ci-linux-debug --config=ci-linux-common --config=ci-limit-storage
-build:ci-linux-debug --config=debug --config=rust-debug
+build:ci-linux-debug --config=debug
 
 build:ci-linux-arm-debug --config=ci-linux-debug
 
 build:ci-linux-asan --config=ci-linux-common --config=ci-limit-storage
 # we're really struggling to fit asan build into worker disk size
 # having asan without symbols is better than none
-build:ci-linux-asan --config=asan --copt="-g0" --strip=always
+build:ci-linux-asan --config=asan --copt="-g0" --@rules_rust//:extra_rustc_flag=-Cdebuginfo=0 --strip=always
 build:ci-linux-arm-asan --config=ci-linux-asan
 
 # Build container tests on Linux CI