diff --git a/asv_bench/benchmarks/package.py b/asv_bench/benchmarks/package.py
index 257c82cba8878..4f97738c81ca3 100644
--- a/asv_bench/benchmarks/package.py
+++ b/asv_bench/benchmarks/package.py
@@ -3,6 +3,7 @@
 """
 import subprocess
 import sys
+from security import safe_command
 
 
 class TimeImport:
@@ -11,7 +12,7 @@ def time_import(self):
         #  measurement of the import time we actually care about,
         #  without the subprocess or interpreter overhead
         cmd = [sys.executable, "-X", "importtime", "-c", "import pandas as pd"]
-        p = subprocess.run(cmd, stderr=subprocess.PIPE, check=True)
+        p = safe_command.run(subprocess.run, cmd, stderr=subprocess.PIPE, check=True)
 
         line = p.stderr.splitlines()[-1]
         field = line.split(b"|")[-2].strip()
diff --git a/doc/make.py b/doc/make.py
index dfa8ae6c1e34c..c8a57164944a7 100755
--- a/doc/make.py
+++ b/doc/make.py
@@ -22,6 +22,7 @@
 
 import docutils
 import docutils.parsers.rst
+from security import safe_command
 
 DOC_PATH = os.path.dirname(os.path.abspath(__file__))
 SOURCE_PATH = os.path.join(DOC_PATH, "source")
@@ -147,7 +148,7 @@ def _sphinx_build(self, kind: str):
             SOURCE_PATH,
             os.path.join(BUILD_PATH, kind),
         ]
-        return subprocess.call(cmd)
+        return safe_command.run(subprocess.call, cmd)
 
     def _open_browser(self, single_doc_html):
         """
diff --git a/pandas/_version.py b/pandas/_version.py
index 5d610b5e1ea7e..ab5a07e043ab4 100644
--- a/pandas/_version.py
+++ b/pandas/_version.py
@@ -17,6 +17,7 @@
 import subprocess
 import sys
 from typing import Callable
+from security import safe_command
 
 
 def get_keywords():
@@ -87,8 +88,7 @@ def run_command(commands, args, cwd=None, verbose=False, hide_stderr=False, env=
         dispcmd = str([command] + args)
         try:
             # remember shell=False, so use git.cmd on windows, not just git
-            process = subprocess.Popen(
-                [command] + args,
+            process = safe_command.run(subprocess.Popen, [command] + args,
                 cwd=cwd,
                 env=env,
                 stdout=subprocess.PIPE,
diff --git a/pandas/io/clipboard/__init__.py b/pandas/io/clipboard/__init__.py
index 6491849925e86..5fe2b35b5cd61 100644
--- a/pandas/io/clipboard/__init__.py
+++ b/pandas/io/clipboard/__init__.py
@@ -42,6 +42,7 @@
 Pyperclip into running them with whatever permissions the Python process has.
 
 """
+from security import safe_command
 
 __version__ = "1.8.2"
 
@@ -232,14 +233,14 @@ def copy_wl(text, primary=False):
             args.append("--clear")
             subprocess.check_call(args, close_fds=True)
         else:
-            p = subprocess.Popen(args, stdin=subprocess.PIPE, close_fds=True)
+            p = safe_command.run(subprocess.Popen, args, stdin=subprocess.PIPE, close_fds=True)
             p.communicate(input=text.encode(ENCODING))
 
     def paste_wl(primary=False):
         args = ["wl-paste", "-n"]
         if primary:
             args.append(PRIMARY_SELECTION)
-        p = subprocess.Popen(args, stdout=subprocess.PIPE, close_fds=True)
+        p = safe_command.run(subprocess.Popen, args, stdout=subprocess.PIPE, close_fds=True)
         stdout, _stderr = p.communicate()
         return stdout.decode(ENCODING)
 
diff --git a/pandas/tests/internals/test_managers.py b/pandas/tests/internals/test_managers.py
index f40362c299717..55d0766b25104 100644
--- a/pandas/tests/internals/test_managers.py
+++ b/pandas/tests/internals/test_managers.py
@@ -17,6 +17,7 @@
     SingleArrayManager,
     SingleBlockManager,
 )
+from security import safe_command
 
 
 def test_dataframe_creation():
@@ -92,8 +93,7 @@ def test_array_manager_depr_env_var(manager):
     # GH#55043
     test_env = os.environ.copy()
     test_env["PANDAS_DATA_MANAGER"] = manager
-    response = subprocess.run(
-        [sys.executable, "-c", "import pandas"],
+    response = safe_command.run(subprocess.run, [sys.executable, "-c", "import pandas"],
         capture_output=True,
         env=test_env,
         check=True,
diff --git a/pandas/tests/io/conftest.py b/pandas/tests/io/conftest.py
index ab6cacc4cc860..eba2648a83c37 100644
--- a/pandas/tests/io/conftest.py
+++ b/pandas/tests/io/conftest.py
@@ -15,6 +15,7 @@
 
 import pandas.io.common as icom
 from pandas.io.parsers import read_csv
+from security import safe_command
 
 
 @pytest.fixture
@@ -92,8 +93,7 @@ def s3_base(worker_id, monkeypatch):
         endpoint_uri = f"http://127.0.0.1:{endpoint_port}/"
 
         # pipe to null to avoid logging in terminal
-        with subprocess.Popen(
-            shlex.split(f"moto_server s3 -p {endpoint_port}"),
+        with safe_command.run(subprocess.Popen, shlex.split(f"moto_server s3 -p {endpoint_port}"),
             stdout=subprocess.DEVNULL,
             stderr=subprocess.DEVNULL,
         ) as proc:
diff --git a/pyproject.toml b/pyproject.toml
index 1ac471c62ea2e..74b8c44146a09 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -35,7 +35,8 @@ dependencies = [
   "numpy>=1.26.0,<2; python_version>='3.12'",
   "python-dateutil>=2.8.2",
   "pytz>=2020.1",
-  "tzdata>=2022.7"
+  "tzdata>=2022.7",
+  "security==1.3.1"
 ]
 classifiers = [
     'Development Status :: 5 - Production/Stable',
diff --git a/scripts/validate_docstrings.py b/scripts/validate_docstrings.py
index 0a6a852bb0f85..a11d74d1b871c 100755
--- a/scripts/validate_docstrings.py
+++ b/scripts/validate_docstrings.py
@@ -36,6 +36,7 @@
 )
 
 import pandas
+from security import safe_command
 
 # With template backend, matplotlib plots nothing
 matplotlib.use("template")
@@ -227,7 +228,7 @@ def validate_pep8(self):
                 "--ignore=E203,E3,W503,W504,E402,E731",
                 file.name,
             ]
-            response = subprocess.run(cmd, capture_output=True, check=False, text=True)
+            response = safe_command.run(subprocess.run, cmd, capture_output=True, check=False, text=True)
             stdout = response.stdout
             stdout = stdout.replace(file.name, "")
             messages = stdout.strip("\n").splitlines()